Article
Role of the p38 MAPK pathway in cisplatin-based therapy.
Oncogene - 26 Jun 2003
Hernández Losa Javier, Parada Cobo Carlos, Guinea Viniegra Juan, Sánchez-Arevalo Lobo Victor Javier, Ramón y Cajal Santiago, Sánchez-Prieto Ricardo
Abstract excerpt
p38 MAPK has been implicated in the response to cancer therapy. To determine whether the activation of p38 MAPK could be specific to cancer therapy, we investigated the activation of p38 MAPK in response to several chemotherapeutic agents, such as cisplatin, doxorubicin and taxol in several human cell lines. Activation of p38 MAPK was measured after exposure to several chemotherapeutic agents, using specific...
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