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Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells

1 Dec 2008

Abstract excerpt

BACKGROUND: Chemoresistance is one of the main obstacles to successful cancer therapy and is frequently associated with Multidrug resistance (MDR). Many different mechanisms have been suggested to explain the development of an MDR phenotype in cancer cells. One of the most studied mechanisms is the overexpression of P-glycoprotein (P-gp), which is a product of the MDR1 gene. Tumor cells often acquire the...

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PMID: 19091131
DOI: 10.1186/1471-2407-8-375

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