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Article

CL100/MKP-1 modulates JNK activation and apoptosis in response to cisplatin.

Oncogene - 26 Oct 2000

Sánchez-Pérez I, Martínez-Gomariz M, Williams D, Keyse S M, Perona R

Abstract excerpt

Treatment of cells with cisplatin induces a sustained activation of the stress activated protein kinase SAPK/JNK and the mitogen-activated protein kinase p38. Activation of JNK by cisplatin is necessary for the induction of apoptosis. Expression of the MAPK phosphatases CL100/MKP-1 and hVH-5 sele...

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Identifiers

PMID: 11064451
DOI: 10.1038/sj.onc.1203887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11064451-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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