Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor

23 Jun 2003

Abstract excerpt

Recently, p53 was demonstrated to affect the expression of the insulin-like growth factor 1 receptor (IGF-1R), a receptor tyrosine kinase that plays a crucial role in growth and survival of cancer cells. However, the underlying mechanisms for interaction between p53 and IGF-1R are still not fully understood. One of the challenging questions remaining to be answered is why the wild-type p53, which per se represses...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12821780
DOI: 10.1073/pnas.1431613100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptorPMID 12821780Read ↗

Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma.Semantic proximity Read ↗

Role of insulin-like growth factor 1 receptor signalling in cancerSemantic proximity Read ↗

Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection PathwaysSemantic proximity Read ↗

Novel Insights into the Molecular Mechanisms Governing Mdm2 Ubiquitination and DestructionSemantic proximity Read ↗

Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression.Semantic proximity Read ↗

Activation of insulin-like growth factor II signaling by mutant type p53: physiological implications for potentiation of IGF-II signaling by p53 mutant 249.Semantic proximity Read ↗

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.Semantic proximity Read ↗

The p53 mRNA-Mdm2 interaction.Semantic proximity Read ↗

Mdm2 mutant defective in binding p300 promotes ubiquitination but not degradation of p53: evidence for the role of p300 in integrating ubiquitination and proteolysis.Semantic proximity Read ↗

The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor.Semantic proximity Read ↗

p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1.Semantic proximity Read ↗

Regulation of Id2 gene expression by the type 1 IGF receptor and the insulin receptor substrate-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.