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Article

Molecular basis for fungal selectivity of novel antimitotic compounds.

Antimicrobial agents and chemotherapy - 1 Jul 2003

Lila Thomas, Renau Thomas E, Wilson Lori, Philips Jay, Natsoulis Georges, Cope M Jamie, Watkins William J, Buysse Jerry

Abstract excerpt

Compounds that selectively disrupt fungal mitosis have proven to be effective in controlling agricultural pests, but no specific mitotic inhibitor is available for the treatment of systemic mycoses in mammalian hosts. In an effort to identify novel mitotic inhibitors, we used a cell-based screening strategy that exploited the hypersensitivity of a yeast alpha-tubulin mutant strain to growth inhibition by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12821479
DOI: 10.1128/AAC.47.7.2273-2282.2003
PMCID: PMC161869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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