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Article

Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity

7 Feb 2007

Abstract excerpt

Blocking cell division through the inhibition of mitosis is one of the most successful clinical strategies for the treatment of cancer. Taxanes and vinca alkaloids are in widespread use and have demonstrated substantive therapeutic efficacy. Both classes of compounds bind directly to tubulin, a structural component of the mitotic spindle. The ubiquitous utilization of tubulin in cell division in both cancerous...

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PMID: 17287337
DOI: 10.1073/pnas.0611340104

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