Article
Molecular basis for determining the sensitivity of eucaryotes to the antimitotic drug rhizoxin.
Molecular & general genetics : MGG - 1 Jul 1990
Takahashi M, Matsumoto S, Iwasaki S, Yahara I
Abstract excerpt
Rhizoxin, an antibiotic, exhibits potent anti-mitotic activity against most eucaryotic cells including those of higher vertebrates, plants and fungi by binding to beta-tubulin. The benA gene of three independently isolated rhizoxin-resistant (Rhir) mutants of Aspergillus nidulans was cloned, sequ...
Topics
- Amino Acid Sequence
- Antifungal Agents
- Aspergillus nidulans
- Base Sequence
- Blotting, Southern
- Cloning, Molecular
- Codon
- DNA, Fungal
- Drug Resistance, Microbial
- Genes, Fungal
- Lactones
- Macrolides
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation
- Restriction Mapping
- Saccharomyces cerevisiae
- Schizosaccharomyces