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Article

Molecular basis for determining the sensitivity of eucaryotes to the antimitotic drug rhizoxin.

Molecular & general genetics : MGG - 1 Jul 1990

Takahashi M, Matsumoto S, Iwasaki S, Yahara I

Abstract excerpt

Rhizoxin, an antibiotic, exhibits potent anti-mitotic activity against most eucaryotic cells including those of higher vertebrates, plants and fungi by binding to beta-tubulin. The benA gene of three independently isolated rhizoxin-resistant (Rhir) mutants of Aspergillus nidulans was cloned, sequenced and compared with that of the wild-type, rhizoxin-sensitive (Rhis) strain. In all three Rhir mutants, the AAC...

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PMID: 2274023
DOI: 10.1007/BF00633814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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