Article
HIV-1 biological phenotype and the development of zidovudine resistance in relation to disease progression in asymptomatic individuals during treatment.
AIDS (London, England) - 1 Nov 1992
Boucher C A, Lange J M, Miedema F F, Weverling G J, Koot M, Mulder J W, Goudsmit J, Kellam P, Larder B A, Tersmette M
Abstract excerpt
OBJECTIVE: To determine which parameters are associated with clinical progression during zidovudine treatment of asymptomatic HIV-1-infected individuals. METHODS: Twenty-four initially asymptomatic HIV-1-infected individuals were treated with zidovudine and followed until the development of AIDS or for approximately 3 years. HIV-1 phenotype was determined by cocultivation of patient cells with donor lymphocytes,...
Topics
- Cytopathogenic Effect, Viral
- Drug Resistance, Microbial
- HIV Infections
- HIV-1
- Humans
- Male
- Mutation
- Phenotype
- RNA-Directed DNA Polymerase
- Time Factors