Article
Monitoring plasma HIV-1 RNA levels in addition to CD4+ lymphocyte count improves assessment of antiretroviral therapeutic response. ACTG 241 Protocol Virology Substudy Team.
Annals of internal medicine - 15 Jun 1997
Hughes M D, Johnson V A, Hirsch M S, Bremer J W, Elbeik T, Erice A, Kuritzkes D R, Scott W A, Spector S A, Basgoz N, Fischl M A, D'Aquila R T
Abstract excerpt
BACKGROUND: CD4+ lymphocyte counts and plasma HIV-1 RNA levels predict progression of HIV-related disease, but the relative importance of these and other virological factors in defining response to antiretroviral therapy is not yet clear. OBJECTIVE: To determine the short-term variability of plasma HIV-1 RNA level during stable therapy; the relative importance of pretreatment values and early changes in CD4+...
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