Article
Enhanced endothelium-dependent vasodilation in subjects with Proline7 substitution in the signal peptide of neuropeptide Y.
Atherosclerosis - 1 Apr 2003
Järvisalo Mikko J, Jartti Laura, Karvonen Matti K, Pesonen Ullamari, Koulu Markku, Marniemi Jukka, Hammar Niklas, Kaprio Jaakko, Paakkunainen Ulla, Simell Olli, Raitakari Olli T, Rönnemaa Tapani
Abstract excerpt
Neuropeptide Y (NPY) is a molecule that may have both vasoconstrictive and vasodilatory actions. A common polymorphism in the human NPY gene that results in the Leucine7 to Proline7 substitution (Leu7Pro) in the signal peptide part of the NPY was recently identified. This substitution has been associated with elevated serum cholesterol levels and with slightly accelerated progression rate of carotid intima-media...
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