Article
Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects.
The Journal of clinical endocrinology and metabolism - 1 Jun 2000
Niskanen L, Karvonen M K, Valve R, Koulu M, Pesonen U, Mercuri M, Rauramaa R, Töyry J, Laakso M, Uusitupa M I
Abstract excerpt
We have recently demonstrated that subjects having Pro7 in the signal peptide ofneuropeptide Y (NPY) have higher serum cholesterol and apolipoprotein B levels than individuals with wild-type (Leu7Leu7) signal peptide sequence. We investigated the association of Leu7Pro polymorphism with common carotid intima media thickness (IMT) assessed by ultrasonograph in patients with type 2 diabetes (n = 81; 41 men and 40...
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