Article
The Leu7Pro polymorphism of preproNPY is associated with decreased insulin secretion, delayed ghrelin suppression, and increased cardiovascular responsiveness to norepinephrine during oral glucose tolerance test.
The Journal of clinical endocrinology and metabolism - 1 Jun 2005
Jaakkola Ulriikka, Kuusela Tom, Jartti Tuomas, Pesonen Ullamari, Koulu Markku, Vahlberg Tero, Kallio Jaana
Abstract excerpt
CONTEXT: Neuropeptide Y (NPY) plays a role in angiogenesis, cardiovascular regulation, and hormone secretion. The leucine7 to proline7 (Leu7Pro) polymorphism of preproNPY is associated with vascular diseases and has an impact on hormone levels in healthy subjects. OBJECTIVE: The current study investigated the role of the Leu7Pro polymorphism in metabolic and cardiovascular autonomic regulation. DESIGN AND...
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