Article
Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels.
Nature medicine - 1 Dec 1998
Karvonen M K, Pesonen U, Koulu M, Niskanen L, Laakso M, Rissanen A, Dekker J M, Hart L M, Valve R, Uusitupa M I
Abstract excerpt
High serum levels of total and LDL cholesterol are important risk factors in the development of atherosclerotic coronary artery disease. Cholesterol metabolism is affected by nutritional, environmental and genetic factors. Neuropeptide Y (NPY), which is widely expressed in both the central and pe...
Topics
- Adult
- Aged
- Alleles
- Amino Acid Substitution
- Cholesterol
- Cholesterol, LDL
- Female
- Gene Frequency
- Genotype
- Humans
- Leucine
- Male
- Middle Aged
- Neuropeptide Y
- Obesity
- Polymorphism, Genetic