Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

From fragile X mental retardation protein to Rac1 GTPase: new insights from Fly CYFIP.

Neuron - 19 Jun 2003

Billuart Pierre, Chelly Jamel

Abstract excerpt

Mutations in either the Rho GTPase pathway or in the fragile X mental retardation (FMR1) gene produce neuronal connectivity defects. In this issue of Neuron, Schenck et al. use biochemical and genetic approaches in Drosophila to examine the interactions between dFMR1 and dRac1 and provide evidence that the cytoplasmic FMRP interacting protein (CYFIP) links Rac-dependent cytoskeleton remodeling and dFMR1-dependent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Drosophila melanogaster
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fragile X Mental Retardation Protein

Share to Intellectual Disability

Share to rac GTP-Binding Proteins

Share to rac1 GTP-Binding Protein

Share to RNA-Binding Proteins

Source

Identifiers

PMID: 12818167
DOI: 10.1016/s0896-6273(03)00362-3

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

From fragile X mental retardation protein to Rac1 GTPase: new insights from Fly CYFIP.PMID 12818167Read ↗

CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein.Semantic proximity Read ↗

Mutational analysis establishes a critical role for the N terminus of fragile X mental retardation protein FMRP.Semantic proximity Read ↗

Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Rac1.Semantic proximity Read ↗

Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain.Semantic proximity Read ↗

Understanding fragile X syndrome: insights from animal models.Semantic proximity Read ↗

Advances in understanding of fragile X pathogenesis and FMRP function, and in identification of X linked mental retardation genes.Semantic proximity Read ↗

Molecular Dissection of Neurodevelopmental Disorder-Causing Mutations in CYFIP2.Semantic proximity Read ↗

Molecular dissection of neurodevelopmental disorder-causing mutations in CYFIP2Semantic proximity Read ↗

The FXR1 network acts as signaling scaffold for actomyosin remodelingSemantic proximity Read ↗

A rapid and dynamic role for FMRP in the plasticity of adult neuronsSemantic proximity Read ↗

WAVE/SCAR, a multifunctional complex coordinating different aspects of neuronal connectivity.Semantic proximity Read ↗

The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.