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Article

Function of Glu-469' in the acid-base catalysis of thioredoxin reductase from Drosophila melanogaster.

Biochemistry - 2 Dec 2008

Huang Hsin-Hung, Arscott L David, Ballou David P, Williams Charles H

Abstract excerpt

Thioredoxin reductase (TrxR) catalyzes the reduction of thioredoxin (Trx) by NADPH. Because dipteran insects such as Drosophila melanogaster lack glutathione reductase, their TrxRs are particularly important for antioxidant protection; reduced Trx reacts nonenzymatically with oxidized glutathione to maintain a high glutathione/glutathione disulfide ratio. Like other members of the pyridine nucleotide-disulfide...

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PMID: 18991392
DOI: 10.1021/bi801449h

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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