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Article

Analysis of GATA1 mutations and leukemogenesis in newborns with Down syndrome.

Genetics and molecular research : GMR - 18 Oct 2013

Queiroz L B, Lima B D, Mazzeu J F, Camargo R, Córdoba M S, Q Magalhães I, Martins-de-Sá C, Ferrari I

Abstract excerpt

It has been reported that patients with Down syndrome (DS) frequently develop transient myeloproliferative disorder (TMD) and less commonly myeloid leukemia in DS (ML-DS). We examined the pathogenetic relationship of these conditions with somatic mutations of the GATA1 gene in children with both TMD and ML-DS. To determine the incidence of GATA1 mutations in a cohort of DS patients and the applicability of these...

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Source

Identifiers

PMID: 24222239
DOI: 10.4238/2013.October.18.1

Genes

GATA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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