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Article

Pore mutants of HERG and KvLQT1 downregulate the reciprocal currents in stable cell lines.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2010

Ren Xiao-Qin, Liu Gong Xin, Organ-Darling Louise E, Zheng Renjian, Roder Karim, Jindal Hitesh K, Centracchio Jason, McDonald Thomas V, Koren Gideon

Abstract excerpt

We previously reported a transgenic rabbit model of long QT syndrome based on overexpression of pore mutants of repolarizing K(+) channels KvLQT1 (LQT1) and HERG (LQT2).The transgenes in these rabbits eliminated the slow and fast components of the delayed rectifier K(+) current (I(Ks) and I(Kr),...

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Identifiers

PMID: 20833965
DOI: 10.1152/ajpheart.00479.2009
PMCID: PMC2993209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20833965-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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