Article
Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone.
Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2004
Carroll Mark C, Girouard Jody B, Ulloa Janella L, Subramaniam Jamuna R, Wong Phillip C, Valentine Joan Selverstone, Culotta Valeria Cizewski
Abstract excerpt
The Cu- and Zn-containing superoxide dismutase 1 (SOD1) largely obtains Cu in vivo by means of the action of the Cu chaperone CCS. Yet, in the case of mammalian SOD1, a secondary pathway of activation is apparent. Specifically, when human SOD1 is expressed in either yeast or mammalian cells that are null for CCS, the SOD1 enzyme retains a certain degree of activity. This CCS-independent activity is evident with...
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