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Article

Immature copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis.

Experimental biology and medicine (Maywood, N.J.) - 1 Oct 2009

Seetharaman Sai V, Prudencio Mercedes, Karch Celeste, Holloway Stephen P, Borchelt David R, Hart P John

Abstract excerpt

Mutations in human copper-zinc superoxide dismutase (SOD1) cause an inherited form of amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease, motor neuron disease). Insoluble forms of mutant SOD1 accumulate in neural tissues of human ALS patients and in spinal cords of transgenic mice expressing these polypeptides, suggesting that SOD1-linked ALS is a protein misfolding disorder. Understanding the molecular...

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Source

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Identifiers

PMID: 19596823
DOI: 10.3181/0903-MR-104
PMCID: PMC2850267

Genes

SOD1
CCS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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