Phosphorylation of CD44 in vivo requires both Ser323 and Ser325, but does not regulate membrane localization or cytoskeletal interaction in epithelial cells.

Abstract excerpt

CD44 has been implicated to play an important role in a diverse range of physiological processes, which involve cell-matrix recognition, cell-cell adhesion and cell motility. There is increasing evidence that the highly conserved intracellular domain of CD44 may be involved in influencing these activities. CD44 is phosphorylated in vivo on serine residue(s). In view of the importance that phosphorylation has been...

Topics

• Amino Acid Sequence
• Animals
• Base Sequence
• Cell Line
• Cell Membrane
• Cytoskeleton
• DNA, Single-Stranded
• Dogs
• Epithelial Cells
• Epithelium
• Fluorescent Antibody Technique