Article
The cytoplasmic tail of CD44 is required for basolateral localization in epithelial MDCK cells but does not mediate association with the detergent-insoluble cytoskeleton of fibroblasts.
The Journal of cell biology - 1 Jun 1993
Neame S J, Isacke C M
Abstract excerpt
A number of recent reports on the trafficking of receptor proteins in MDCK epithelial cells have provided evidence that delivery to the basolateral domain requires a specific targeting sequence and that deletion of this sequence results in constitutive expression on the apical surface. To date, t...
Topics
- Animals
- Base Sequence
- Biological Transport
- Cell Line
- Cell Polarity
- Cytoskeleton
- Dogs
- Epithelium
- Fibroblasts
- Humans
- Microscopy, Fluorescence
- Molecular Sequence Data
- Mutation
- Receptors, Lymphocyte Homing
- Structure-Activity Relationship