Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TIF1γ requires sumoylation to exert its repressive activity on TGFβ signaling

1 Jan 2013

Abstract excerpt

TIF1γ, a new regulator of TGFβ signaling, inhibits the Smad4-mediated TGFβ response by interaction with Smad2/3 or ubiquitylation of Smad4. We have shown that TIF1γ participates in TGFβ signaling as a negative regulator of Smad4 during the TGFβ-induced epithelial-to-mesenchymal transition (EMT) in mammary epithelial cells, and during terminal differentiation of mammary alveolar epithelial cells and lactation. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Genetic factors in colorectal cancer
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23788427
DOI: 10.1242/jcs.126748

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TIF1γ requires sumoylation to exert its repressive activity on TGFβ signalingPMID 23788427Read ↗

The ubiquitin ligase Smurf2 suppresses TGFβ-induced epithelial–mesenchymal transition in a sumoylation-regulated mannerSemantic proximity Read ↗

SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4.Semantic proximity Read ↗

Sumoylated SnoN interacts with HDAC1 and p300/CBP to regulate EMT-associated phenotypes in mammary organoids.Semantic proximity Read ↗

Antagonistic regulation of EMT by TIF1γ and Smad4 in mammary epithelial cellsSemantic proximity Read ↗

Dysregulated PJA1-TGF-β signaling in cancer stem cell-associated liver cancersSemantic proximity Read ↗

PRMT5 methylating Smad4 activates TGF-β signaling and promotes colorectal cancer metastasisSemantic proximity Read ↗

Transcriptional cofactors Ski and SnoN are major regulators of the TGF-β/Smad signaling pathway in health and diseaseSemantic proximity Read ↗

Repression of TIF1γ by SOX2 promotes TGF-β-induced epithelial–mesenchymal transition in non-small-cell lung cancerSemantic proximity Read ↗

SENP5 mediates breast cancer invasion via a TGFβRI SUMOylation cascade.Semantic proximity Read ↗

The Post-translational Modifications of Smurf2 in TGF-β SignalingSemantic proximity Read ↗

Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin.Semantic proximity Read ↗

Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.