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Article

Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary disease.

The Journal of clinical investigation - 1 Jun 2003

Barton Erik S, Youree Bryan E, Ebert Daniel H, Forrest J Craig, Connolly Jodi L, Valyi-Nagy Tibor, Washington Kay, Wetzel J Denise, Dermody Terence S

Abstract excerpt

Infection of neonatal mice with some reovirus strains produces a disease similar to infantile biliary atresia, but previous attempts to correlate reovirus infection with this disease have yielded conflicting results. We used isogenic reovirus strains T3SA- and T3SA+, which differ solely in the capacity to bind sialic acid as a coreceptor, to define the role of sialic acid in reovirus encephalitis and biliary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12813018
DOI: 10.1172/JCI16303
PMCID: PMC161418

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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