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Diversity in Rotavirus–Host Glycan Interactions: A “Sweet” Spectrum

12 Mar 2016

Abstract excerpt

Interaction with cellular glycans is a critical initial step in the pathogenesis of many infectious agents. Technological advances in glycobiology have expanded the repertoire of studies delineating host glycan–pathogen interactions. For rotavirus, the VP8* domain of the outer capsid spike protein VP4 is known to interact with cellular glycans. Sialic acid was considered the key cellular attachment factor for...

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PMID: 28090561
DOI: 10.1016/j.jcmgh.2016.03.002

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