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Characterization of Histophilus somni sialic acid uptake mutant (ΔnanP-ΔnanU) using a mouse septicemia and mortality model.

Microbial pathogenesis - 1 Sept 2024

Menghwar Harish, Tatum Fred M, Briggs Robert E, Kanipe Carly, Casas Eduardo, Kaptur Jean, Kaplan Bryan S, Inzana Thomas J, Azadi Parastoo, Dassanayake Rohana P

Abstract excerpt

Histophilus somni is an important pathogen of the bovine respiratory disease complex, yet the mechanisms underlying its virulence remain poorly understood. It is known that H. somni can incorporate sialic acid into lipooligosaccharide (LOS), and sialylated H. somni is more resistant to phagocytosis and complement-mediated killing by serum compared to non-sialylated bacteria in vitro. However, the virulence of...

Topics

Animals
Mice
Disease Models, Animal
N-Acetylneuraminic Acid
Pasteurellaceae
Virulence
Sepsis
Lipopolysaccharides
Female
Mutation
Cattle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Bacterial Proteins

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Identifiers

PMID: 39103126
DOI: 10.1016/j.micpath.2024.106839

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