Article
Identification of the sialic acid structures recognized by minute virus of mice and the role of binding affinity in virulence adaptation.
The Journal of biological chemistry - 1 Sept 2006
Nam Hyun-Joo, Gurda-Whitaker Brittney, Gan Wand Yee, Ilaria Shawen, McKenna Robert, Mehta Padmaja, Alvarez Richard A, Agbandje-McKenna Mavis
Abstract excerpt
Sialic acid binding is required for infectious cell surface receptor recognition by parvovirus minute virus of mice (MVM). We have utilized a glycan array consisting of approximately 180 different carbohydrate structures to identify the specific sialosides recognized by the prototype (MVMp) and immunosuppressive (MVMi) strains of MVM plus three virulent mutants of MVMp, MVMp-I362S, MVMp-K368R, and...
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