Article
Detection of mutations in quinolone resistance-determining regions in levofloxacin- and methicillin-resistant Staphylococcus aureus: effects of the mutations on fluoroquinolone MICs.
Diagnostic microbiology and infectious disease - 1 Jun 2003
Horii Toshinobu, Suzuki Yasuhiro, Monji Akio, Morita Motoki, Muramatsu Hideaki, Kondo Yoko, Doi Matsuko, Takeshita Akihiro, Kanno Takashi, Maekawa Masato
Abstract excerpt
The minimum inhibitory concentrations (MICs) of 18 antibiotics were determined for 66 clinical isolates of staphylococci. Genotypes, mutations in the quinolone resistance-determining regions (QRDRs), and effect of efflux were determined in the 18 levofloxacin-resistant isolates, for which the MICs of levofloxacin were high (> or =8 microg/ml). The increased levofloxacin resistance mainly resulted from some...
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