Article
Emerging multiple mutations and high-level fluoroquinolone resistance in methicillin-resistant Staphylococcus aureus isolated from ocular infections.
Diagnostic microbiology and infectious disease - 1 Nov 2006
Iihara Hirotoshi, Suzuki Takashi, Kawamura Yoshiaki, Ohkusu Kiyofumi, Inoue Yasushi, Zhang Wei, Monir Shah Mohammad, Katagiri Yoshihiro, Ohashi Yuichi, Ezaki Takayuki
Abstract excerpt
We investigated the prevalence of mutations in the gyrA, gyrB, grlA, and grlB genes in 21 clinical isolates of methicillin-resistant Staphylococcus aureus recovered from ocular infections. These isolates were classified into 16 groups on the basis of pulsed-field gel electrophoresis (PFGE) patterns. Among these nonidentical strains, 9 different combinations of mutations were observed. We observed an unusually...
Topics
- Drug Resistance, Bacterial
- Drug Resistance, Multiple
- Eye Infections
- Fluoroquinolones
- Genes, Bacterial
- Humans
- Methicillin Resistance
- Microbial Sensitivity Tests
- Multidrug Resistance-Associated Proteins
- Mutation
- Staphylococcal Infections