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Article

Association between bone loss and promoter polymorphism in the IL-6 gene in elderly Japanese women with hip fracture.

Journal of bone and mineral metabolism - 1 Jan 2003

Feng Dongyun, Ishibashi Hideaki, Yamamoto Seizo, Hosoi Takayuki, Orimo Hajime, Machida Takeo, Koshihara Yasuko

Abstract excerpt

Recently, a G/C polymorphism was found at position -573 of the interleukin-6 ( IL-6) gene promoter. We investigated how this genetic polymorphism relates to IL-6 production and osteoporosis in elderly Japanese women. Genomic DNA was extracted from an aliquot of monocytes in the bone marrow; the monocytes were simultaneously used to form osteoclast-like multinucleated cells (MNCs) and to produce IL-6. Of the 47...

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Source

Identifiers

PMID: 12811627
DOI: 10.1007/s00774-003-0413-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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