Article
Association of the G-174C variant in the interleukin-6 promoter region with bone loss and fracture risk in older women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2004
Moffett Susan P, Zmuda Joseph M, Cauley Jane A, Stone Katie L, Nevitt Michael C, Ensrud Kristine E, Hillier Teresa A, Hochberg Marc C, Joslyn Geoff, Morin Phillip, Cummings Steven R
Abstract excerpt
UNLABELLED: We analyzed the association between the IL-6 G-174C polymorphism and osteoporosis phenotypes in 3376 older women. Women with the C/C genotype had a significantly slower rate of decline in hip BMD and a 33% lower risk of wrist fracture than women with the G/G genotype. Variation at the IL-6 locus may contribute to the genetic susceptibility to bone fragility. INTRODUCTION: Interleukin 6 (IL-6) promotes...
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