Characterization of newly established tumor lines from a spontaneous malignant schwannoma in F344 rats: nerve growth factor production, growth inhibition by transforming growth factor-beta1, and macrophage-like phenotype expression.

doi:10.1007/s00401-003-0723-0

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Article

Characterization of newly established tumor lines from a spontaneous malignant schwannoma in F344 rats: nerve growth factor production, growth inhibition by transforming growth factor-beta1, and macrophage-like phenotype expression.

Acta neuropathologica - 1 Sept 2003

Yamate J, Yasui H, Benn S J, Tsukamoto Y, Kuwamura M, Kumagai D, Sakuma S, LaMarre J

Abstract excerpt

Transplantable tumor (KE) and clone cell (KE-F11) lines were established from a spontaneous malignant schwannoma found in an aged F344 rat. The primary tumor and KE tumors consisted of oval or spindle cells arranged in ill-defined bundles. Cultured KE-F11 cells exhibited polygonal or spindle configurations. Immunohistochemically, neoplastic cells in KE and KE-F11 reacted to vimentin, S-100 protein,...

Topics

Actins
Animals
Blotting, Northern
Cell Count
Cell Line, Transformed
Desmin
Dose-Response Relationship, Drug
Genes, jun
Genes, myc
Glial Fibrillary Acidic Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Vitro Techniques

Keratins

Lipopolysaccharides

Macrophages

Male

Microscopy, Electron

Myelin Basic Protein

Nerve Growth Factor

Source

Open in PubMed

Identifiers

PMID: 12811582
DOI: 10.1007/s00401-003-0723-0

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