Phenotypic modulation in cisplatin-resistant cloned cells derived from transplantable rat malignant fibrous histiocytoma.

doi:10.1111/j.1440-1827.1996.tb03654.x

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Article

Phenotypic modulation in cisplatin-resistant cloned cells derived from transplantable rat malignant fibrous histiocytoma.

Pathology international - 1 Aug 1996

Yamate J, Tajima M, Shibuya K, Kuwamura M, Kotani T, Sakuma S

Abstract excerpt

The histogenesis of malignant fibrous histiocytoma (MFH) was studied using cisplatin (CDDP)-resistant MT-R8 and MT-R9 cells derived from cloned undifferentiated MT-8 and fibrohistiocytic MT-9 cells, respectively, which had been established from transplantable rat MFH. CDDP concentrations required for 50% suppression of proliferation of MT-R8 and MT-R9 cells were 5.4- and 3.3-fold greater than those of parental...

Topics

Animals
Cisplatin
Clone Cells
Drug Resistance, Neoplasm
Histiocytoma, Benign Fibrous
Neoplasm Transplantation
Phenotype
Rats
Tumor Cells, Cultured

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Identifiers

PMID: 8893224
DOI: 10.1111/j.1440-1827.1996.tb03654.x

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