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Article

Carboxy-terminal mutations of bile acid CoA:N-acyltransferase alter activity and substrate specificity.

Journal of lipid research - 1 Jul 2016

Styles Nathan A, Shonsey Erin M, Falany Josie L, Guidry Amber L, Barnes Stephen, Falany Charles N

Abstract excerpt

Bile acid CoA:amino acid N-acyltransferase (BAAT) is the terminal enzyme in the synthesis of bile salts from cholesterol and catalyzes the conjugation of taurine or glycine to bile acid CoA thioesters to form bile acid N-acylamidates. BAAT has a dual localization to the cytosol and peroxisomes, possibly due to an inefficient carboxy-terminal peroxisomal targeting signal (PTS), -serine-glutamine-leucine (-SQL)....

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Source

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Identifiers

PMID: 27230263
DOI: 10.1194/jlr.M064428
PMCID: PMC4918843

Genes

BAAT
PTS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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