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Article

Ergosterol is required for targeting of tryptophan permease to the yeast plasma membrane.

The Journal of cell biology - 23 Jun 2003

Umebayashi Kyohei, Nakano Akihiko

Abstract excerpt

It was known that the uptake of tryptophan is reduced in the yeast erg6 mutant, which is defective in a late step of ergosterol biosynthesis. Here, we show that this is because the high affinity tryptophan permease Tat2p is not targeted to the plasma membrane. In wild-type cells, the plasma membrane localization of Tat2p is regulated by the external tryptophan concentration. Tat2p is transported from the Golgi...

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Identifiers

PMID: 12810702
DOI: 10.1083/jcb.200303088
PMCID: PMC2172991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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