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Screens for mutants defective in UapA trafficking highlight the importance of ER-exit as a primary control point in transporter biogenesis.

Fungal genetics and biology : FG & B - 1 Dec 2024

Demos Effie, Dimou Sofia, Scazzocchio Claudio, Diallinas George

Abstract excerpt

Most transmembrane membrane proteins are thought to traffic to the plasma membrane (PM) via the conventional secretory pathway through sorting from the Golgi. However, our recent work has shown that in the filamentous fungus Aspergillus nidulans several nutrient transporters and other major membrane proteins traffic to the PM via Golgi-bypass and independently of known post-Golgi secretory mechanisms. Here in an...

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PMID: 39521172
DOI: 10.1016/j.fgb.2024.103940

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