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Article

The G2-phase decatenation checkpoint is defective in Werner syndrome cells.

Cancer research - 15 Jun 2003

Franchitto Annapaola, Oshima Junko, Pichierri Pietro

Abstract excerpt

It has been proposed that cells monitor chromatid catenation status after DNA replication and inhibit progression into mitosis until chromatids are correctly decatenated by topoisomerase II (TopoII). Studies in yeast have suggested that TopoII may interact with RecQ helicases during this process. Using ICRF187, a TopoII catalytic inhibitor that prevents chromatid decatenation without producing DNA strand breaks,...

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Topics

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Share to DNA Helicases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12810661

Genes

WRN
ATR
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The G2-phase decatenation checkpoint is defective in Werner syndrome cells.PMID 12810661Read ↗

WRN helicase regulates the ATR–CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I–DNA covalent complexesSemantic proximity Read ↗

The human decatenation checkpointSemantic proximity Read ↗

Rad51 and Mitotic Function of Mus81 are Essential for Recovery from Low-Dose of Camptothecin in the Absence of the Wrn ExonucleaseSemantic proximity Read ↗

Topoisomerase IIalpha controls the decatenation checkpoint.Semantic proximity Read ↗

The Drosophila Werner exonuclease participates in an exonuclease-independent response to replication stress.Semantic proximity Read ↗

Nucleotide excision repair deficiency causes elevated levels of chromosome gain in Saccharomyces cerevisiae.Semantic proximity Read ↗

Loss of Werner syndrome protein function promotes aberrant mitotic recombination.Semantic proximity Read ↗

A novel mutant allele of the chromatin-bound fission yeast checkpoint protein Rad17 separates the DNA structure checkpoints.Semantic proximity Read ↗

Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cellsSemantic proximity Read ↗

Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.Semantic proximity Read ↗

HRad17 Colocalizes with NHP2L1 in the Nucleolus and Redistributes after UV IrradiationSemantic proximity Read ↗

ATM pathway activation limits R-loop-associated genomic instability in Werner syndrome cellsSemantic proximity Read ↗

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