Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation.

Molecular and cellular biology - 1 Jul 2003

Phan Vernon T, Shultz David B, Truong Bao-Tran H, Blake Timothy J, Brown Anna L, Gonda Thomas J, Le Beau Michelle M, Kogan Scott C

Abstract excerpt

We utilized a mouse model of acute promyelocytic leukemia (APL) to investigate how aberrant activation of cytokine signaling pathways interacts with chimeric transcription factors to generate acute myeloid leukemia. Expression in mice of the APL-associated fusion, PML-RARA, initially has only modest effects on myelopoiesis. Whereas treatment of control animals with interleukin-3 (IL-3) resulted in expanded...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Cells
Share to Immunophenotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-3

Share to Oncogene Proteins, Fusion

Share to Retroviridae

Share to Spleen

Share to src Homology Domains

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 12808098
DOI: 10.1128/MCB.23.13.4573-4585.2003
PMCID: PMC164846

Genes

PML
RARA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation.PMID 12808098Read ↗

PML/RARα and FLT3-ITD induce an APL-like disease in a mouse modelSemantic proximity Read ↗

Leukemia initiated by PMLRARalpha: the PML domain plays a critical role while retinoic acid-mediated transactivation is dispensable.Semantic proximity Read ↗

Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice identify cooperating events and genetic pathways to acute promyelocytic leukemiaSemantic proximity Read ↗

Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia.Semantic proximity Read ↗

Two critical hits for promyelocytic leukemia.Semantic proximity Read ↗

PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in miceSemantic proximity Read ↗

Transgenic expression of PML/RARalpha impairs myelopoiesis.Semantic proximity Read ↗

Retinoic acid receptor alpha (RAralpha) Mutations in Human Leukemia.Semantic proximity Read ↗

A <i>PMLRAR</i> α transgene initiates murine acute promyelocytic leukemiaSemantic proximity Read ↗

Oncogenic K-ras cooperates with PML-RAR to induce an acute promyelocytic leukemia-like diseaseSemantic proximity Read ↗

A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia.Semantic proximity Read ↗

A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.