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Article

Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action.

Molecular and cellular biology - 1 Jul 2003

Trencia Alessandra, Perfetti Anna, Cassese Angela, Vigliotta Giovanni, Miele Claudia, Oriente Francesco, Santopietro Stefania, Giacco Ferdinando, Condorelli Gerolama, Formisano Pietro, Beguinot Francesco

Abstract excerpt

The antiapoptotic protein PED/PEA-15 features an Akt phosphorylation motif upstream from Ser(116). In vitro, recombinant PED/PEA-15 was phosphorylated by Akt with a stoichiometry close to 1. Based on Western blotting with specific phospho-Ser(116) PED/PEA-15 antibodies, Akt phosphorylation of PED/PEA-15 occurred mainly at Ser(116). In addition, a mutant of PED/PEA-15 featuring the substitution of Ser(116)-->Gly...

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Identifiers

PMID: 12808093
DOI: 10.1128/MCB.23.13.4511-4521.2003
PMCID: PMC164852

Genes

BAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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