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Article

HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals.

Nature medicine - 1 Nov 2001

Wolf D, Witte V, Laffert B, Blume K, Stromer E, Trapp S, d'Aloja P, Schürmann A, Baur A S

Abstract excerpt

A highly conserved signaling property of Nef proteins encoded by human or simian immunodeficiency virus is the binding and activation of a PAK kinase whose function is unclear. Here we show that Nef-mediated p21-activated kinase (PAK) activation involves phosphatidylinositol 3-kinase, which acts upstream of PAK and is bound and activated by Nef similar to the manner of Polyoma virus middle T antigen. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11689886
DOI: 10.1038/nm1101-1217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals.PMID 11689886Read ↗

Lentivirus Nef specifically activates Pak2.Semantic proximity Read ↗

Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX.Semantic proximity Read ↗

p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD.Semantic proximity Read ↗

Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2Semantic proximity Read ↗

p21-Activated Kinase 1 Plays a Critical Role in Cellular Activation by NefSemantic proximity Read ↗

[PI3K-AKT network roles in infectious diseases].Semantic proximity Read ↗

Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice.Semantic proximity Read ↗

“UnPAKing” Human Immunodeficiency Virus (HIV) Replication: Using Small Interfering RNA Screening To Identify Novel Cofactors and Elucidate the Role of Group I PAKs in HIV InfectionSemantic proximity Read ↗

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis.Semantic proximity Read ↗

Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses.Semantic proximity Read ↗

Activation of the PI3K-AKT Pathway by Old World AlphavirusesSemantic proximity Read ↗

The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis.Semantic proximity Read ↗

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