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Article

A three-tiered mechanism for regulation of planar cell polarity.

Seminars in cell & developmental biology - 1 Jun 2002

Tree David R P, Ma Dali, Axelrod Jeffrey D

Abstract excerpt

Some epithelial cells are polarized along an axis orthogonal to their apical-basal axes. Recent studies in Drosophila lead to the view that three classes of signaling molecules govern the planar cell polarity (PCP) pathway. The first class, or module, functions across whole tissues, providing directional information to individual cells. The second module, apparently shared by all planar polarized tissues, and...

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PMID: 12137730
DOI: 10.1016/s1084-9521(02)00042-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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