Article
The mutant selection window and antimicrobial resistance.
The Journal of antimicrobial chemotherapy - 1 Jul 2003
Drlica Karl
Abstract excerpt
The mutant selection window is an antimicrobial concentration range extending from the minimal concentration required to block the growth of wild-type bacteria up to that required to inhibit the growth of the least susceptible, single-step mutant. The upper boundary is also called the mutant prevention concentration (MPC). Placing antimicrobial concentrations inside the window is expected to enrich resistant...
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