Article
Analysis of IGF2 gene imprinting in breast and colorectal cancer by allele specific-PCR.
The Journal of pathology - 1 Apr 1999
Yun K, Soejima H, Merrie A E, McCall J L, Reeve A E
Abstract excerpt
The insulin-like growth factor II (IGF2) gene is imprinted with the paternal allele expressed and the maternal one silent. Loss of imprinting (LOI) of IGF2 has been suggested to play a role in the development of tumours, but the reported incidence of IGF2 LOI in tumours shows considerable variation, which may stem from different methodologies employed. In particular, partial digestion of reverse...
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