Article
Genomic imprinting of IGF-II and H19 in adult human pancreatic tissues.
Digestion - 1 Jan 2000
Micha A E, Hähnel S, Friess H, Büchler M W, Adler G, Gress T M
Abstract excerpt
BACKGROUND/AIM: Genomic imprinting is a chromosomal modification causing differential expression of maternal and paternal alleles. Loss of imprinting (LOI) of IGF-II and H19 has been suggested to be an early oncogenic event in cancerogenesis. Aim of the present study was to describe the status of IGF-II and H19 imprinting in adult human pancreatic tissues. METHODS: Allele-specific gene expression was studied...
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