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Article

MHC and malaria: the relationship between HLA class II alleles and immune responses to Plasmodium falciparum.

International immunology - 1 Sept 1992

Riley E M, Olerup O, Bennett S, Rowe P, Allen S J, Blackman M J, Troye-Blomberg M, Holder A A, Greenwood B M

Abstract excerpt

In mice, immune responses to subunits of defined malaria antigens are regulated by genes mapping within the MHC and it has been suggested that such genetic restriction will be a major obstacle in the development of a human malaria vaccine. The relationship between class II human leukocyte antigen (HLA) genes and immune recognition of three candidate antigens for a vaccine against Plasmodium falciparum malaria has...

Topics

Adolescent
Adult
Aged
Alleles
Animals
Antibodies, Protozoan
Child
Child, Preschool
Genes, MHC Class II
HLA-DQ Antigens
HLA-DR Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haplotypes

Humans

Middle Aged

Plasmodium falciparum

Source

Identifiers

PMID: 1390436
DOI: 10.1093/intimm/4.9.1055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1390436-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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