Article
Antibody cross-linking of the glycosylphosphatidylinositol-linked protein CD59 on hematopoietic cells induces signaling pathways resembling activation by complement.
The Journal of biological chemistry - 25 Sept 1998
Murray E W, Robbins S M
Abstract excerpt
CD59 is a glycosylphosphatidylinositol-anchored cell surface glycoprotein involved in protecting cells from host-mediated complement attack. Studies have shown that antibody cross-linking of CD59 induces a series of intracellular signaling events including the activation of protein-tyrosine kinas...
Topics
- Antibodies
- Bone Marrow Cells
- CD59 Antigens
- Cell Line
- Humans
- Phenotype
- Phosphorylation
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-cbl
- Signal Transduction
- Tyrosine
- Ubiquitin-Protein Ligases