Article
Dystroglycan depletion inhibits the functions of differentiated HL-60 cells.
Biochemical and biophysical research communications - 6 Jun 2014
Martínez-Zárate Alma Delia, Martínez-Vieyra Ivette, Alonso-Rangel Lea, Cisneros Bulmaro, Winder Steve J, Cerecedo Doris
Abstract excerpt
Dystroglycan has recently been characterized in blood tissue cells, as part of the dystrophin glycoprotein complex but to date nothing is known of its role in the differentiation process of neutrophils. We have investigated the role of dystroglycan in the human promyelocytic leukemic cell line HL-60 differentiated to neutrophils. Depletion of dystroglycan by RNAi resulted in altered morphology and reduced...
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