Article
Inherited breast cancer: an emerging picture.
Clinical genetics - 1 Dec 1998
Welcsh P L, Schubert E L, King M C
Abstract excerpt
A role for BRCA1 and BRCA2 in the control of genome integrity easily fits a tumor suppressor model. It is well established that mutations in DNA repair genes lead to genomic instability (138). Genomic instability may directly lead to tumorigenesis by allowing for the accumulation of mutations in key cell cycle regulators (139). The studies summarized here suggest that BRCA1, BRCA2, RAD51. and BARD1 function as a...
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