Article
Role of peroxisome proliferator-activated receptor gamma Pro12Ala polymorphism in human adipose tissue: assessment of adipogenesis and adipocyte glucose and lipid turnover.
Adipocyte - 1 Jan 2018
Kamble Prasad G, Pereira Maria J, Gustafsson Stefan, Lundkvist Per, Castillejo-López Casimiro, Fall Tove, Ingelsson Erik, Eriksson Jan W
Abstract excerpt
The protective mechanisms of peroxisome proliferator-activated receptor gamma (PPARγ) Pro12Ala polymorphism in type 2 diabetes (T2D) are unclear. We obtained subcutaneous adipose tissue (AT) before and 3 h after oral glucose (OGTT) in carriers and non-carriers of the Ala allele (12 Pro/Pro, 15 Pro/Ala, and 13 Ala/Ala). Adipogenesis, adipocyte glucose uptake and lipolysis as well as PPARγ target gene expression...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.