Article
[Polymorphism of pro12Ala in peroxisome proliferator activated receptor gamma 2 (PPAgamma2): beta cell function and insulin sensitivity].
Deutsche medizinische Wochenschrift (1946) - 18 May 2001
Fritsche A, Madaus A, Tschritter O, Ozeker M, Wulle E L, Machicao F, Häring H, Stumvoll M
Abstract excerpt
BACKGROUND AND OBJECTIVE: The peroxisome proliferator-activated receptor isoform gamma (PPAR gamma) is a key regulator in lipid and glucose homoeostasis. A common polymorphism (Pro12Ala in PPAR gamma 2, prevalence ca. 25%) was shown to be associated with a decreased risk of type 2 diabetes. Generally, both beta-cell dysfunction and insulin resistance contribute to the development of type 2 diabetes. Therefore,...
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