Article
A novel STK11 germline mutation in two siblings with Peutz-Jeghers syndrome complicated by primary gastric cancer.
Clinical genetics - 1 Jan 2005
Shinmura K, Goto M, Tao H, Shimizu S, Otsuki Y, Kobayashi H, Ushida S, Suzuki K, Tsuneyoshi T, Sugimura H
Abstract excerpt
Patients with Peutz-Jeghers syndrome (PJS) are known to be at risk of gastric cancer (GC), and the STK11 gene is a susceptibility gene for PJS. However, as no cases of PJS with GC in which a STK11 germline mutation has been identified have ever been reported and other susceptibility genes have also been suggested to be involved in PJS, the relation between STK11 germline mutations and GC in PJS is still unknown....
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